ABSTRACT
This study has shown that serum activity of cathepsin B, cathepsin D and B-NAG were insignificantly decreased in rheumatoid group compared with normal group while serum acid phosphatase was significantly increased in rheumatoid arthritis when compared with normal group. Synovial activity of cathepsin B, cathepsin D, B-NAG and acid phosphatase were significantly increased in rheumatoid group compared with osteoarthritic group. B-NAG is fractionated in rheumatoid synovial fluid into 2 bands [A, B], where A band had disappeared by heating, while in, osteoarthritic synovial fluid B-NAG had been fractionated into only one band [A], which had disappeared by heating
Subject(s)
Synovial Fluid , Cathepsins , Cathepsin B , Cathepsin D , Acid Phosphatase , AcetylglucosaminidaseABSTRACT
The concentration of malondialdehyde in serum and syovial fluid was measured as an indicator of free radical in 20 arthritic patients [10 osteoarthritis and 10 rheumatoid arthritis] plus ten healthy volunteers. Free radical activity showed high significant increase in rheumatoid group compared with both control and osteoarthritic groups, this increase was manifested both in serums as well as in synovial fluid. From this study it is concluded that, measurement of free radicals are useful in diagnosis of rheumatoid arthritis. The study strongly recommend the administration of antioxidants side by side with antirheumatic drugs to correct the oxidative stress and promote oxidant antioxidant balance